EFFECT OF ALOE VERA AND CINNAMOMUM TAMALA ON BODY WEIGHT AND FEED INTAKE OF INDUCED DIABETIC MICE

Abstract

Intraperitoneal injection of alloxanmonohydrate (200mg/kg)was used to induce diabetes in mice, with blood glucose levels(fasting) morethan 150mg/dl. Sixty nine mice were divided into 4 groups, Group I was non diabetic (normal). Group II was diabetic, Group III was the diabetic and treated with Cinnamomumtamala and group IV was diabetic and Aloe vera treated. There was no increase in the blood glucoseat random and fasting in group Iwhereas, group II showed an increase in blood sugar level (91.00±2.65mg/dl to 250.00±3.79mg/dl) post 21 days. Cinnamomumtamala (50mg/kg) and Aloe vera (400mg/kg) appeared effective in reducing the blood sugar levels after 21 days treatment. There was an increase in intake of feed and drop in body weight of group II compared to group I. Cinnamomumtamala (50mg/kg) and Aloe vera (400mg/kg) was found effective regarding decrease in feed intake. Increase in weight of mice occurred treated with Cinnamomumtamala (50mg/kg) and Aloe vera (400mg/kg)as compared to diabetic mice. Cinnamomumtamala and Aloe vera were potentially efficient to treat hyperglycemia at recommended oral doses of 50 mg/kg and 400mg/kg of body weight respectively.